Critical Role of TLR4 on the Microglia Activation Induced by Maternal LPS Exposure Leading to ASD-Like Behavior of Offspring

Critical Role of TLR4 on the Microglia Activation Induced by Maternal LPS Exposure Leading to ASD-Like Behavior of Offspring

Objective: To investigate the role of TLR4 on the microglia activation in the pre-frontal cortex, which leads to autism-like behavior of the offspring induced by maternal lipopolysaccharide (LPS) exposure.Methods: Pregnant TLR4−/− (knockout, KO) and WT (wild type, WT) dams were intraperitoneally inj...

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Bibliographic Details
Main Authors: Lu Xiao, Junyan Yan, Di Feng, Shasha Ye, Ting Yang, Hua Wei, Tingyu Li, Wuqing Sun, Jie Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
toll-like receptor 4
autism spectrum disorder
lipopolysaccharide
microglia
synaptic pruning
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.634837/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.634837/full

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