PTENP1 is a ceRNA for PTEN: it’s CRISPR clear

PTENP1 is a ceRNA for PTEN: it’s CRISPR clear

Abstract Here we apply state-of-the-art CRISPR technologies to study the impact that PTENP1 pseudogene transcript has on the expression levels of its parental gene PTEN, and hence on the output of AKT signaling in cancer. Our data expand the repertoire of approaches that can be used to dissect compe...

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Bibliographic Details
Main Authors: Marianna Vitiello, Monica Evangelista, Yang Zhang, Leonardo Salmena, Pier Paolo Pandolfi, Laura Poliseno
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Hematology & Oncology
Subjects:
PTENP1
PTEN
ceRNA
CRISPR
CasRx-mediated knock-down
Cas9-mediated knock-in
Online Access:http://link.springer.com/article/10.1186/s13045-020-00894-2

Internet

http://link.springer.com/article/10.1186/s13045-020-00894-2

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