An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer

An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer

Objective: The statin family of cholesterol-lowering drugs has been shown to induce tumor-specific apoptosis by inhibiting the rate-limiting enzyme of the mevalonate (MVA) pathway, HMG-CoA reductase (HMGCR). Accumulating evidence suggests that statin use may delay prostate cancer (PCa) progression i...

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Bibliographic Details
Main Authors: Joseph Longo, Peter J. Mullen, Rosemary Yu, Jenna E. van Leeuwen, Mehdi Masoomian, Dixon T.S. Woon, Yuzhuo Wang, Eric X. Chen, Robert J. Hamilton, Joan M. Sweet, Theodorus H. van der Kwast, Neil E. Fleshner, Linda Z. Penn
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877819300882

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http://www.sciencedirect.com/science/article/pii/S2212877819300882

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