Dysregulation of PAK1 Is Associated with DNA Damage and Is of Prognostic Importance in Primary Esophageal Small Cell Carcinoma

Dysregulation of PAK1 Is Associated with DNA Damage and Is of Prognostic Importance in Primary Esophageal Small Cell Carcinoma

Primary esophageal small cell carcinoma (PESCC) is a rare, but fatal subtype of esophageal carcinoma. No effective therapeutic regimen for it. P21-activated kinase 1 (PAK1) is known to function as an integrator and an indispensable node of major growth factor signaling and the molecular therapy targ...

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Bibliographic Details
Main Authors: Jinfeng Gan, Yuling Zhang, Xiurong Ke, Chong Tan, Hongzheng Ren, Hongmei Dong, Jiali Jiang, Shaobin Chen, Yixuan Zhuang, Hao Zhang
Format: Article
Language:English
Published: MDPI AG 2015-05-01
Series:International Journal of Molecular Sciences
Subjects:
primary esophageal small cell carcinoma
p21-activated kinase 1
DNA damage
γH2AX
metastasis
prognosis
Online Access:http://www.mdpi.com/1422-0067/16/6/12035

Internet

http://www.mdpi.com/1422-0067/16/6/12035

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