A Transgenic Mouse Model of Pacak–Zhuang Syndrome with An <i>Epas1</i> Gain-of-Function Mutation

A Transgenic Mouse Model of Pacak–Zhuang Syndrome with An <i>Epas1</i> Gain-of-Function Mutation

We previously identified a novel syndrome in patients characterized by paraganglioma, somatostatinoma, and polycythemia. In these patients, polycythemia occurs long before any tumor develops, and tumor removal only partially corrects polycythemia, with recurrence occurring shortly after surgery. Gen...

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Bibliographic Details
Main Authors: Herui Wang, Jing Cui, Chunzhang Yang, Jared S. Rosenblum, Qi Zhang, Qi Song, Ying Pang, Francia Fang, Mitchell Sun, Pauline Dmitriev, Mark R. Gilbert, Graeme Eisenhofer, Karel Pacak, Zhengping Zhuang
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cancers
Subjects:
paraganglioma
somatostatinoma
polycythemia
<i>EPAS1</i>
transgenic mice
erythropoietin
Online Access:https://www.mdpi.com/2072-6694/11/5/667

Internet

https://www.mdpi.com/2072-6694/11/5/667

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