Mapping Determinants of Cytokine Signaling via Protein Engineering

Mapping Determinants of Cytokine Signaling via Protein Engineering

Cytokines comprise a large family of secreted ligands that are critical for the regulation of immune homeostasis. Cytokines initiate signaling via dimerization or oligomerization of the cognate receptor subunits, triggering the activation of the Janus Kinases (JAKs)/ signal transducer and activator...

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Bibliographic Details
Main Authors: Claire Gorby, Jonathan Martinez-Fabregas, Stephan Wilmes, Ignacio Moraga
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
cytokine signaling
protein engineering
JAK/STAT signaling pathway
endosomal trafficking
endosomes signaling
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02143/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02143/full

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