A new algorithm to train hidden Markov models for biological sequences with partial labels

Abstract Background Hidden Markov models (HMM) are a powerful tool for analyzing biological sequences in a wide variety of applications, from profiling functional protein families to identifying functional domains. The standard method used for HMM training is either by maximum likelihood using count...

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Bibliographic Details
Main Authors: Jiefu Li, Jung-Youn Lee, Li Liao
Format: Article
Language:English
Published: BMC 2021-03-01
Series:BMC Bioinformatics
Subjects:
Online Access:https://doi.org/10.1186/s12859-021-04080-0