Dietary Fiber-Induced Microbial Short Chain Fatty Acids Suppress ILC2-Dependent Airway Inflammation

Dietary Fiber-Induced Microbial Short Chain Fatty Acids Suppress ILC2-Dependent Airway Inflammation

Group 2 Innate lymphoid cells (ILC2) contribute significantly to allergic inflammation. However, the role of microbiota on ILC2s remains to be unraveled. Here we show that short chain fatty acids (SCFAs), such as butyrate, derived from fermentation of dietary fibers by the gut microbiota inhibit pul...

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Bibliographic Details
Main Authors: Gavin Lewis, Bowen Wang, Pedram Shafiei Jahani, Benjamin P. Hurrell, Homayon Banie, German R. Aleman Muench, Hadi Maazi, Doumet Georges Helou, Emily Howard, Lauriane Galle-Treger, Richard Lo, Swetha Santosh, Andrew Baltus, Gerrold Bongers, Lani San-Mateo, Frank D. Gilliland, Virender K. Rehan, Pejman Soroosh, Omid Akbari
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
dietary fiber
short chain fatty acid
ILC2
airway hyperreactivity
allergic disease
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02051/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02051/full

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