Dietary Fiber-Induced Microbial Short Chain Fatty Acids Suppress ILC2-Dependent Airway Inflammation
Group 2 Innate lymphoid cells (ILC2) contribute significantly to allergic inflammation. However, the role of microbiota on ILC2s remains to be unraveled. Here we show that short chain fatty acids (SCFAs), such as butyrate, derived from fermentation of dietary fibers by the gut microbiota inhibit pul...
Main Authors: | Gavin Lewis, Bowen Wang, Pedram Shafiei Jahani, Benjamin P. Hurrell, Homayon Banie, German R. Aleman Muench, Hadi Maazi, Doumet Georges Helou, Emily Howard, Lauriane Galle-Treger, Richard Lo, Swetha Santosh, Andrew Baltus, Gerrold Bongers, Lani San-Mateo, Frank D. Gilliland, Virender K. Rehan, Pejman Soroosh, Omid Akbari |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2019-09-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.02051/full |
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