O-alkylated quercetins with selective acetylcholinesterase and β-secretase inhibitions from Melicope glabra leaves, and their flavonols profile by LC-ESI-Q-TOF/MS

O-alkylated quercetins with selective acetylcholinesterase and β-secretase inhibitions from Melicope glabra leaves, and their flavonols profile by LC-ESI-Q-TOF/MS

Intensive investigation of phytochemicals from edible Melicope glabra leaves provided a series of O-alkylated quercetins (1–13). The quercetin 1 bearing prenyl and methyl motif showed potent inhibition to human acetylcholinesterase (hAChE) with mixed type I mode, while quercetin was inactive. The po...

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Bibliographic Details
Main Authors: Aizhamal Baiseitova, Abdul Bari Shah, Jeong Yoon Kim, Yeong Jun Ban, Jeong Ho Kim, Mohd Azlan Nafiah, Ki Hun Park
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Journal of Functional Foods
Subjects:
Melicope glabra
Acetylcholinesterase
β-secretase
Antioxidant
Pteleifolosin C
Pteleifolosin E
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464621002516

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http://www.sciencedirect.com/science/article/pii/S1756464621002516

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