Simvastatin Sensitizes Radioresistant Prostate Cancer Cells by Compromising DNA Double-Strand Break Repair

Simvastatin Sensitizes Radioresistant Prostate Cancer Cells by Compromising DNA Double-Strand Break Repair

Prostate cancer (PCa) is one of the most prevalent male cancers in western world. Radiation therapy (RT) is commonly used to treat PCa patients. However, a certain proportion of patients develop radioresistant PCa cells, which results in metastatic disease. Statins, which inhibit 3-hydroxy-3-methyl...

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Bibliographic Details
Main Authors: Yu-An Chen, Hua-Wei Shih, Yi-Chun Lin, Hui-Ying Hsu, Tsu-Fang Wu, Chen-Han Tsai, Chia-Lin Wu, Hui-Yu Wu, Jer-Tsong Hsieh, Chih-Hsin Tang, Chih-Ho Lai
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Pharmacology
Subjects:
cholesterol
HMG-CoA reductase
simvastatin
prostate cancer
radioresistance
DNA double-strand break
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00600/full

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https://www.frontiersin.org/article/10.3389/fphar.2018.00600/full

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