Sirt3 Exerts Its Tumor-Suppressive Role by Increasing p53 and Attenuating Response to Estrogen in MCF-7 Cells

Sirt3 Exerts Its Tumor-Suppressive Role by Increasing p53 and Attenuating Response to Estrogen in MCF-7 Cells

Estrogen (E2) is a major risk factor for the initiation and progression of malignancy in estrogen receptor (ER) positive breast cancers, whereas sirtuin 3 (Sirt3), a major mitochondrial NAD<sup>+</sup>-dependent deacetylase, has the inhibitory effect on the tumorigenic properties of ER p...

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Bibliographic Details
Main Authors: Marija Pinterić, Iva I. Podgorski, Marijana Popović Hadžija, Vedrana Filić, Mladen Paradžik, Bastien Lucien Jean Proust, Ana Dekanić, Ivan Ciganek, Denis Pleše, Dora Marčinko, Tihomir Balog, Sandra Sobočanec
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Antioxidants
Subjects:
sirtuin 3
MCF-7
estrogen receptor
p53
breast cancer cells
Online Access:https://www.mdpi.com/2076-3921/9/4/294

Internet

https://www.mdpi.com/2076-3921/9/4/294

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