Increased vulnerability of nigral dopamine neurons after expansion of their axonal arborization size through D2 dopamine receptor conditional knockout.

Increased vulnerability of nigral dopamine neurons after expansion of their axonal arborization size through D2 dopamine receptor conditional knockout.

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopamine (DA) neurons in the substantia nigra pars compacta (SNc). Rare genetic mutations in genes such as Parkin, Pink1, DJ-1, α-synuclein, LRRK2 and GBA are found to be responsible for the disease in about 1...

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Bibliographic Details
Main Authors: Nicolas Giguère, Benoît Delignat-Lavaud, Freja Herborg, Aurore Voisin, Yuan Li, Vincent Jacquemet, Madhu Anand-Srivastava, Ulrik Gether, Bruno Giros, Louis-Éric Trudeau
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-08-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008352

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https://doi.org/10.1371/journal.pgen.1008352

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