H3.3 kinetics predicts chromatin compaction status of parental genomes in early embryos

Abstract Background After fertilization, the fusion of gametes results in the formation of totipotent zygote. During sperm-egg fusion, maternal factors participate in parental chromatin remodeling. H3.3 is a histone H3 variant that plays essential roles in mouse embryogenesis. Methods Here, we used...

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Bibliographic Details
Main Authors: Shi-meng Guo, Xing-ping Liu, Li-quan Zhou
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Reproductive Biology and Endocrinology
Subjects:
Online Access:https://doi.org/10.1186/s12958-021-00776-3