Phylogenomic analyses reveal the evolutionary origin of the inhibin alpha-subunit, a unique TGFbeta superfamily antagonist.

Phylogenomic analyses reveal the evolutionary origin of the inhibin alpha-subunit, a unique TGFbeta superfamily antagonist.

Transforming growth factor-beta (TGFbeta) homologues form a diverse superfamily that arose early in animal evolution and control cellular function through membrane-spanning, conserved serine-threonine kinases (RII and RI receptors). Activin and inhibin are related dimers within the TGFbeta superfami...

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Bibliographic Details
Main Authors: Jie Zhu, Edward L Braun, Satomi Kohno, Monica Antenos, Eugene Y Xu, Robert W Cook, S Jack Lin, Brandon C Moore, Louis J Guillette, Theodore S Jardetzky, Teresa K Woodruff
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2832003?pdf=render

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http://europepmc.org/articles/PMC2832003?pdf=render

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