Study of subcellular localization and proteolysis of ataxin-3

Study of subcellular localization and proteolysis of ataxin-3

In this work we investigate subcellular localization and proteolytic cleavage of different forms of ataxin-3 (AT-3), the protein responsible for spinocerebellar ataxia type 3. Normal (AT-3Q6 and AT-3Q26) and pathological (AT-3Q72) ataxins-3, as well as two truncated forms lacking poly-Q, were studie...

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Bibliographic Details
Main Authors: Chiara Pozzi, Marco Valtorta, Gabriella Tedeschi, Elena Galbusera, Valentina Pastori, Alessandra Bigi, Simona Nonnis, Eleonora Grassi, Paola Fusi
Format: Article
Language:English
Published: Elsevier 2008-05-01
Series:Neurobiology of Disease
Subjects:
Ataxin-3
Spinocerebellar ataxia type 3
Poly-Q
Proteolysis
Protein aggregation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108000077

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http://www.sciencedirect.com/science/article/pii/S0969996108000077

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