Central Ceramide-Induced Hypothalamic Lipotoxicity and ER Stress Regulate Energy Balance

Central Ceramide-Induced Hypothalamic Lipotoxicity and ER Stress Regulate Energy Balance

Summary: Hypothalamic endoplasmic reticulum (ER) stress is a key mechanism leading to obesity. Here, we demonstrate that ceramides induce lipotoxicity and hypothalamic ER stress, leading to sympathetic inhibition, reduced brown adipose tissue (BAT) thermogenesis, and weight gain. Genetic overexpress...

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Bibliographic Details
Main Authors: Cristina Contreras, Ismael González-García, Noelia Martínez-Sánchez, Patricia Seoane-Collazo, Jordi Jacas, Donald A. Morgan, Dolors Serra, Rosalía Gallego, Francisco Gonzalez, Núria Casals, Rubén Nogueiras, Kamal Rahmouni, Carlos Diéguez, Miguel López
Format: Article
Language:English
Published: Elsevier 2014-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714007335

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http://www.sciencedirect.com/science/article/pii/S2211124714007335

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