Synthetic SARS-CoV-2 Spike-Based DNA Vaccine Elicits Robust and Long-Lasting Th1 Humoral and Cellular Immunity in Mice

Synthetic SARS-CoV-2 Spike-Based DNA Vaccine Elicits Robust and Long-Lasting Th1 Humoral and Cellular Immunity in Mice

The ongoing global pandemic of coronavirus disease 2019 (COVID-19) calls for an urgent development of effective and safe prophylactic and therapeutic measures. The spike (S) glycoprotein of severe acute respiratory syndrome-coronavirus (SARS-CoV-2) is a major immunogenic and protective protein and p...

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Bibliographic Details
Main Authors: Sawsan S. Alamri, Khalid A. Alluhaybi, Rowa Y. Alhabbab, Mohammad Basabrain, Abdullah Algaissi, Sarah Almahboub, Mohamed A. Alfaleh, Turki S. Abujamel, Wesam H. Abdulaal, M-Zaki ElAssouli, Rahaf H. Alharbi, Mazen Hassanain, Anwar M. Hashem
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Microbiology
Subjects:
COVID-19
SARS-CoV-2
plasmid DNA
spike (S) glycoprotein
preclinical (in vivo) studies
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.727455/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2021.727455/full

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