Neddylation Promotes Ubiquitylation and Release of Ku from DNA-Damage Sites

Neddylation Promotes Ubiquitylation and Release of Ku from DNA-Damage Sites

The activities of many DNA-repair proteins are controlled through reversible covalent modification by ubiquitin and ubiquitin-like molecules. Nonhomologous end-joining (NHEJ) is the predominant DNA double-strand break (DSB) repair pathway in mammalian cells and is initiated by DSB ends being recogni...

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Bibliographic Details
Main Authors: Jessica S. Brown, Natalia Lukashchuk, Matylda Sczaniecka-Clift, Sébastien Britton, Carlos le Sage, Patrick Calsou, Petra Beli, Yaron Galanty, Stephen P. Jackson
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715003496

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http://www.sciencedirect.com/science/article/pii/S2211124715003496

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