WNT3a and WNT5a Transported by Exosomes Activate WNT Signaling Pathways in Human Cardiac Fibroblasts

WNT3a and WNT5a Transported by Exosomes Activate WNT Signaling Pathways in Human Cardiac Fibroblasts

WNT signaling plays an important role in fibrotic processes in the heart. Recently, exosomes have been proposed as novel extracellular transporters for WNT proteins. In this study, we analyzed whether WNT3a and WNT5a carried by exosomes could activate downstream molecular pathways in human cardiac f...

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Bibliographic Details
Main Authors: Edyta Działo, Michał Rudnik, Roman I. Koning, Marcin Czepiel, Karolina Tkacz, Monika Baj-Krzyworzeka, Oliver Distler, Maciej Siedlar, Gabriela Kania, Przemysław Błyszczuk
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
exosomes
WNT3a
WNT5a
cardiac fibroblasts
canonical WNT
non-canonical WNT
cardiovascular diseases
Online Access:https://www.mdpi.com/1422-0067/20/6/1436

Internet

https://www.mdpi.com/1422-0067/20/6/1436

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