SLT-VEGF Reduces Lung Metastases, Decreases Tumor Recurrence, and Improves Survival in an Orthotopic Melanoma Model

SLT-VEGF Reduces Lung Metastases, Decreases Tumor Recurrence, and Improves Survival in an Orthotopic Melanoma Model

SLT-VEGF is a recombinant cytotoxin comprised of Shiga-like toxin (SLT) subunit A fused to human vascular endothelial growth factor (VEGF). It is highly cytotoxic to tumor endothelial cells overexpressing VEGF receptor-2 (VEGFR-2/KDR/Flk1) and inhibits the growth of primary tumors in subcutaneous mo...

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Bibliographic Details
Main Authors: Sini Skariah, Carl V. Hamby, Marina Backer, Rachel Ackerman, Joseph M. Backer
Format: Article
Language:English
Published: MDPI AG 2010-08-01
Series:Toxins
Subjects:
biological therapeutics
shiga-like toxin
SLT-VEGF
melanoma
angiogenesis
metastasis
VEGF receptor targeting
Online Access:http://www.mdpi.com/2072-6651/2/9/2242/

Internet

http://www.mdpi.com/2072-6651/2/9/2242/

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