A Targeted Gene Panel That Covers Coding, Non-coding and Short Tandem Repeat Regions Improves the Diagnosis of Patients With Neurodegenerative Diseases

A Targeted Gene Panel That Covers Coding, Non-coding and Short Tandem Repeat Regions Improves the Diagnosis of Patients With Neurodegenerative Diseases

Genetic testing for neurodegenerative diseases (NDs) is highly challenging because of genetic heterogeneity and overlapping manifestations. Targeted-gene panels (TGPs), coupled with next-generation sequencing (NGS), can facilitate the profiling of a large repertoire of ND-related genes. Due to the t...

Full description

Bibliographic Details
Main Authors: Allen Chi-Shing Yu, Aldrin Kay-Yuen Yim, Anne Yin-Yan Chan, Liz Y. P. Yuen, Wing Chi Au, Timothy H. T. Cheng, Xiao Lin, Jing-Woei Li, Larry W. L. Chan, Vincent C. T. Mok, Ting-Fung Chan, Ho Yin Edwin Chan
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Neuroscience
Subjects:
neurodegenerative diseases
undiagnosed diseases
gene panel
short tandem repeat
clinical decision support
high-throughput sequencing
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.01324/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.01324/full

Similar Items