Antigenic Variation of the Dengue Virus 2 Genotypes Impacts the Neutralization Activity of Human Antibodies in Vaccinees

Antigenic Variation of the Dengue Virus 2 Genotypes Impacts the Neutralization Activity of Human Antibodies in Vaccinees

Summary: Dengue virus (DENV) infects an estimated 390 million people each year worldwide. As tetravalent DENV vaccines have variable efficacy against DENV serotype 2 (DENV2), we evaluated the role of genetic diversity within the pre-membrane (prM) and envelope (E) proteins of DENV2 on vaccine perfor...

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Bibliographic Details
Main Authors: David R. Martinez, Boyd Yount, Usha Nivarthi, Jennifer E. Munt, Matthew J. Delacruz, Stephen S. Whitehead, Anna P. Durbin, Aravinda M. de Silva, Ralph S. Baric
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Cell Reports
Subjects:
dengue virus 2
prM and E protein genetic variation
genotype
antibody
neutralization
vaccines
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720312158

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http://www.sciencedirect.com/science/article/pii/S2211124720312158

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