Aerosol delivery of synthetic DNA containing CpG motifs in broiler chicks at hatch under field conditions using a commercial-scale prototype nebulizer provided protection against lethal Escherichia coli septicemia

Aerosol delivery of synthetic DNA containing CpG motifs in broiler chicks at hatch under field conditions using a commercial-scale prototype nebulizer provided protection against lethal Escherichia coli septicemia

Synthetic DNA containing CpG motifs (CpG-ODN) are potent innate immune stimulators in neonatal and adult broiler chickens against bacterial septicemia. We have recently demonstrated that intrapulmonary (IPL) delivery of CpG-ODN as microdroplets under laboratory conditions can protect neonatal chicke...

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Bibliographic Details
Main Authors: K.B. Goonewardene, S. Popowich, S. Gebhardt, T. Gunawardana, A. Gupta, S. Kurukulasuriya, R. Karunarathna, M. Liu, B. Chow-Lockerbie, L. Ayalew, K.A. Ahmed, Houman Kamali, S.K. Tikoo, M. Foldvari, P. Willson, J. Boire, K. Roberts, N. Ambrose, C. Simonson, S. Gomis
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Poultry Science
Subjects:
hatchery
commercial-scale poultry nebulizer
immunoprotection
neonatal broiler
Online Access:http://www.sciencedirect.com/science/article/pii/S0032579120309858

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http://www.sciencedirect.com/science/article/pii/S0032579120309858

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