Biomarker discovery by integrated joint non-negative matrix factorization and pathway signature analyses

Abstract Predictive biomarkers are important for selecting appropriate patients for particular treatments. Comprehensive genomic, transcriptomic, and pharmacological data provide clues for understanding relationships between biomarkers and drugs. However, it is still difficult to mine biologically m...

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Bibliographic Details
Main Authors: Naoya Fujita, Shinji Mizuarai, Katsuhiko Murakami, Kenta Nakai
Format: Article
Language:English
Published: Nature Publishing Group 2018-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-28066-w