FMRP regulates the subcellular distribution of cortical dendritic spine density in a non-cell-autonomous manner

FMRP regulates the subcellular distribution of cortical dendritic spine density in a non-cell-autonomous manner

Fragile X syndrome (FXS) is the most common form of intellectual disability that arises from the dysfunction of a single gene—Fmr1. The main neuroanatomical correlate of FXS is elevated dendritic spine density on cortical pyramidal neurons, which has been modeled in Fmr1-/Y mice. However, the cell-a...

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Bibliographic Details
Main Authors: Katherine M. Bland, Adam Aharon, Eden L. Widener, M. Irene Song, Zachary O. Casey, Yi Zuo, George S. Vidal
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Neurobiology of Disease
Subjects:
Fragile X Syndrome
Fmr1
Dendritic spine
Dendrite
Layer V
Layer 5
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121000024

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http://www.sciencedirect.com/science/article/pii/S0969996121000024

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