Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS Generation.

Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS Generation.

The chemotherapeutic use of cisplatin is limited by its severe side effects. In this study, by conducting different omics data analyses, we demonstrated that cisplatin induces cell death in a proximal tubular cell line by suppressing glycolysis- and tricarboxylic acid (TCA)/mitochondria-related gene...

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Main Authors: Yong-Min Choi, Han-Kyul Kim, Wooyoung Shim, Muhammad Ayaz Anwar, Ji-Woong Kwon, Hyuk-Kwon Kwon, Hyung Joong Kim, Hyobin Jeong, Hwan Myung Kim, Daehee Hwang, Hyung Sik Kim, Sangdun Choi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4527592?pdf=render

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http://europepmc.org/articles/PMC4527592?pdf=render

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