Deuterated Arachidonic Acids Library for Regulation of Inflammation and Controlled Synthesis of Eicosanoids: An In Vitro Study

Deuterated Arachidonic Acids Library for Regulation of Inflammation and Controlled Synthesis of Eicosanoids: An In Vitro Study

The synthesis of signal lipids, including eicosanoids, is not fully understood, although it is key to the modulation of various inflammatory states. Recently, isotopologues of essential polyunsaturated fatty acids (PUFAs) deuterated at bis-allylic positions (D-PUFAs) have been proposed as inhibitors...

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Bibliographic Details
Main Authors: Dmitry V. Chistyakov, Ivan S. Filimonov, Nadezhda V. Azbukina, Sergei V. Goriainov, Viktor V. Chistyakov, Maksim A. Fomich, Andrei V. Bekish, Vadim V. Shmanai, Marina G. Sergeeva, Mikhail S. Shchepinov
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Molecules
Subjects:
human 15-lipoxygenase-2
human 5-lipoxygenase
human cyclooxygenase 2
deuterated arachidonic acids
eicosanoids
isotope effect
Online Access:https://www.mdpi.com/1420-3049/23/12/3331

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https://www.mdpi.com/1420-3049/23/12/3331

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