Engineering of Humanized Antibodies Against Human Interleukin 5 Receptor Alpha Subunit That Cause Potent Antibody-Dependent Cell-Mediated Cytotoxicity

Engineering of Humanized Antibodies Against Human Interleukin 5 Receptor Alpha Subunit That Cause Potent Antibody-Dependent Cell-Mediated Cytotoxicity

Patients with severe eosinophilic asthma (SEA; characterized by persistent eosinophilia in blood and airway tissues) experience frequent asthma exacerbations with poor clinical outcomes. Interleukin 5 (IL-5) and IL-5 receptor alpha subunit (IL-5α) play key roles in eosinophilia maintenance, and rele...

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Bibliographic Details
Main Authors: Jung-Eun Kim, Dong-Hyun Lee, Keunok Jung, Eun-Ji Kim, Youngwoo Choi, Hae-Sim Park, Yong-Sung Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
IL-5
IL-5 receptor
eosinophil
antagonistic antibody
severe asthma
antibody-dependent cell-mediated cytotoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.593748/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.593748/full

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