Modeling hallmark pathology using motor neurons derived from the family and sporadic amyotrophic lateral sclerosis patient-specific iPS cells

Modeling hallmark pathology using motor neurons derived from the family and sporadic amyotrophic lateral sclerosis patient-specific iPS cells

Abstract Background Amyotrophic lateral sclerosis (ALS) represents a devastating, progressive, heterogeneous, and the most common motor neuron (MN) disease. To date, no cure has been available for the condition. Studies with transgenic mice have yielded significant results that help us understand th...

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Bibliographic Details
Main Authors: Xuejiao Sun, Jianyuan Song, Hailong Huang, Hong Chen, Kun Qian
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Stem Cell Research & Therapy
Subjects:
Amyotrophic lateral sclerosis
TDP-43
Induced pluripotent cells
Neurofilament
Mitochondria
Online Access:http://link.springer.com/article/10.1186/s13287-018-1048-1

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http://link.springer.com/article/10.1186/s13287-018-1048-1

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