Thrombospondin-1 contributes to mortality in murine sepsis through effects on innate immunity.

Thrombospondin-1 contributes to mortality in murine sepsis through effects on innate immunity.

BACKGROUND:Thrombospondin-1 (TSP-1) is involved in many biological processes, including immune and tissue injury response, but its role in sepsis is unknown. Cell surface expression of TSP-1 on platelets is increased in sepsis and could activate the anti-inflammatory cytokine transforming growth fac...

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Main Authors: Sara McMaken, Matthew C Exline, Payal Mehta, Melissa Piper, Yijie Wang, Sara N Fischer, Christie A Newland, Carrie A Schrader, Shannon R Balser, Anasuya Sarkar, Christopher P Baran, Clay B Marsh, Charles H Cook, Gary S Phillips, Naeem A Ali
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3090410?pdf=render

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http://europepmc.org/articles/PMC3090410?pdf=render

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