Mineralocorticoid receptor stimulation induces urinary storage dysfunction via upregulation of epithelial sodium channel expression in the rat urinary bladder epithelium

Mineralocorticoid receptor stimulation induces urinary storage dysfunction via upregulation of epithelial sodium channel expression in the rat urinary bladder epithelium

We aimed to evaluate mineralocorticoid receptor (MR) expression in rat bladder and the physiological role of the MR-epithelial sodium channel (ENaC) pathway in controlling bladder function in 10–12-week-old, male Sprague–Dawley rats. First, we examined the mRNA expression of MR and localization of M...

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Bibliographic Details
Main Authors: Seiji Yamamoto, Yuji Hotta, Kotomi Maeda, Tomoya Kataoka, Yasuhiro Maeda, Takashi Hamakawa, Shoichi Sasaki, Takahiro Yasui, Kiyofumi Asai, Kazunori Kimura
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Journal of Pharmacological Sciences
Subjects:
Mineralocorticoid receptor
Epithelial sodium channel
Overactive bladder
Cystometry
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861316000256

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http://www.sciencedirect.com/science/article/pii/S1347861316000256

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