Pilocarpine-Induced Status Epilepticus Is Associated with P-Glycoprotein Induction in Cardiomyocytes, Electrocardiographic Changes, and Sudden Death

Pilocarpine-Induced Status Epilepticus Is Associated with P-Glycoprotein Induction in Cardiomyocytes, Electrocardiographic Changes, and Sudden Death

Sudden unexpected death in epilepsy (SUDEP) is the major cause of death in those patients suffering from refractory epilepsy (RE), with a 24-fold higher risk relative to the normal population. SUDEP risk increases with seizure frequency and/or seizure-duration as in RE and Status Epilepticus (SE). P...

Full description

Bibliographic Details
Main Authors: Jerónimo Auzmendi, Bruno Buchholz, Jimena Salguero, Carlos Cañellas, Jazmín Kelly, Paula Men, Marcela Zubillaga, Alicia Rossi, Amalia Merelli, Ricardo J. Gelpi, Alberto J. Ramos, Alberto Lazarowski
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Pharmaceuticals
Subjects:
Status Epilepticus
SUDEP
HIF-1α
hypoxia
P-glycoprotein
cardiomyocytes
QT prolongation
Online Access:http://www.mdpi.com/1424-8247/11/1/21

Internet

http://www.mdpi.com/1424-8247/11/1/21

Similar Items