Integrated Systems Approach Reveals Sphingolipid Metabolism Pathway Dysregulation in Association with Late-Onset Alzheimer’s Disease

Integrated Systems Approach Reveals Sphingolipid Metabolism Pathway Dysregulation in Association with Late-Onset Alzheimer’s Disease

Late-onset Alzheimer’s disease (LOAD) and age are significantly correlated such that one-third of Americans beyond 85 years of age are afflicted. We have designed and implemented a pilot study that combines systems biology approaches with traditional next-generation sequencing (NGS) analysis techniq...

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Bibliographic Details
Main Authors: John Stephen Malamon, Andres Kriete
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Biology
Subjects:
Alzheimer’s disease
aging
sphingolipid metabolism
autophagy
co-expression modeling
eQTL
gene set enrichment analysis
Online Access:http://www.mdpi.com/2079-7737/7/1/16

Internet

http://www.mdpi.com/2079-7737/7/1/16

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