Anthralin Suppresses the Proliferation of Influenza Virus by Inhibiting the Cap-Binding and Endonuclease Activity of Viral RNA Polymerase

Anthralin Suppresses the Proliferation of Influenza Virus by Inhibiting the Cap-Binding and Endonuclease Activity of Viral RNA Polymerase

Influenza virus RNA-dependent RNA polymerase (vRdRp) does not have capping activity and relies on the capped RNAs produced by the host RNA polymerase II (RNAPII). The viral polymerases process the capped RNAs to produce short capped RNA fragments that are used as primers to initiate the transcriptio...

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Bibliographic Details
Main Authors: Ao Hu, Jing Li, Wei Tang, Ge Liu, Haiwei Zhang, Chunlan Liu, Xulin Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Microbiology
Subjects:
influenza
cap snatching
vRdRp
anthralin
cap-binding
endonuclease
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00178/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.00178/full

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