Complex regulation of acute and chronic neuroinflammatory responses in mouse models deficient for nuclear factor kappa B p50 subunit

Complex regulation of acute and chronic neuroinflammatory responses in mouse models deficient for nuclear factor kappa B p50 subunit

Inflammation is a major mechanism of acute brain injury and chronic neurodegeneration. This neuroinflammation is known to be substantially regulated by the transcription factor NF-κB, which is predominantly found in the form of heterodimer of p65 (RelA) and p50 subunit, with p50/p50 homodimers being...

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Bibliographic Details
Main Authors: Taisia Rolova, Lakshman Puli, Johanna Magga, Hiramani Dhungana, Katja Kanninen, Sara Wojciehowski, Antero Salminen, Heikki Tanila, Jari Koistinaho, Tarja Malm
Format: Article
Language:English
Published: Elsevier 2014-04-01
Series:Neurobiology of Disease
Subjects:
Microglia
Beta-amyloid
Inflammation
Cytokines
Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113003392

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http://www.sciencedirect.com/science/article/pii/S0969996113003392

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