Pioglitazone and Deoxyribonucleoside Combination Treatment Increases Mitochondrial Respiratory Capacity in m.3243A>G MELAS Cybrid Cells

Pioglitazone and Deoxyribonucleoside Combination Treatment Increases Mitochondrial Respiratory Capacity in m.3243A>G MELAS Cybrid Cells

The lack of effective treatments for mitochondrial disease has seen the development of new approaches, including those that aim to stimulate mitochondrial biogenesis to boost ATP generation above a critical disease threshold. Here, we examine the effects of the peroxisome proliferator-activated rece...

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Bibliographic Details
Main Authors: Harrison J. Burgin, M. Isabel G. Lopez Sanchez, Craig M. Smith, Ian A. Trounce, Matthew McKenzie
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
mitochondrial biogenesis
mitochondrial disease
oxidative phosphorylation
oxphos
pioglitazone
deoxyribonucleosides
melas
cybrid
Online Access:https://www.mdpi.com/1422-0067/21/6/2139

Internet

https://www.mdpi.com/1422-0067/21/6/2139

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