Genetic Alterations and Resectability Predict Outcome in Patients with Neuroblastoma Assigned to High-Risk Solely by <i>MYCN</i> Amplification

Genetic Alterations and Resectability Predict Outcome in Patients with Neuroblastoma Assigned to High-Risk Solely by <i>MYCN</i> Amplification

Background: To identify variables predicting outcome in neuroblastoma patients assigned to the high-risk group solely by the presence of <i>MYCN</i> oncogene amplification (MNA). Methods: Clinical characteristics, genomic information, and outcome of 190 patients solely assigned to high-r...

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Bibliographic Details
Main Authors: Frank Berthold, Angela Ernst, Sandra Ackermann, Christoph Bartenhagen, Holger Christiansen, Barbara Hero, Carolina Rosswog, Dietrich von Schweinitz, Thomas Klingebiel, Irene Schmid, Thorsten Simon, Matthias Fischer
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
high-risk neuroblastoma
<i>MYCN</i> amplification
<i>RAS</i> pathway
p53 pathway
<i>ALK</i>
resectability
Online Access:https://www.mdpi.com/2072-6694/13/17/4360

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https://www.mdpi.com/2072-6694/13/17/4360

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