Thrombopoietin enhances hematopoietic stem and progenitor cell homing by impeding matrix metalloproteinase 9 expression

Thrombopoietin enhances hematopoietic stem and progenitor cell homing by impeding matrix metalloproteinase 9 expression

Abstract We reported a novel function of recombinant human thrombopoietin (TPO) in increasing hematopoietic stem and progenitor cell (HSPC) homing to the bone marrow (BM). Single doses of TPO treatment to the recipients immediately after BM transplantation showed significantly improved homing of HSP...

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Bibliographic Details
Main Authors: Yiming Liu, Li Ding, Bowen Zhang, Ziliang Deng, Yi Han, Sihan Wang, Shu Yang, Zeng Fan, Jing Zhang, Hongmin Yan, Dongmei Han, Lijuan He, Wen Yue, Hengxiang Wang, Yanhua Li, Xuetao Pei
Format: Article
Language:English
Published: Wiley 2020-06-01
Series:Stem Cells Translational Medicine
Subjects:
engraftment
hematopoietic stem and progenitor cells
homing
matrix metalloproteinase 9
thrombopoietin
Online Access:https://doi.org/10.1002/sctm.19-0220

Internet

https://doi.org/10.1002/sctm.19-0220

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