Protective effect of luteolin on streptozotocin-induced diabetic renal damage in mice via the regulation of RIP140/NF-кB pathway and insulin signalling pathway
Luteolin (LUT) is one of the most common flavonoids present in various fruits and vegetables. The effects of luteolin (LUT) on streptozotocin (STZ)-induced diabetic renal damage were investigated. LUT was orally administered at 10, 20 mg/kg/day for 4 weeks to streptozotocin-induced diabetic mice. Se...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2016-04-01
|
Series: | Journal of Functional Foods |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464616000268 |
id |
doaj-f0cb2b5ba312433ea9553b086156f834 |
---|---|
record_format |
Article |
spelling |
doaj-f0cb2b5ba312433ea9553b086156f8342021-04-30T07:07:14ZengElsevierJournal of Functional Foods1756-46462016-04-012293100Protective effect of luteolin on streptozotocin-induced diabetic renal damage in mice via the regulation of RIP140/NF-кB pathway and insulin signalling pathwayLvyi Chen0Guowen Tian1Weidong Tang2Wei Luo3Peng Liu4Zhanqiang Ma5School of Pharmacy, South-Central University for Nationalities, Wuhan 430074, China; Corresponding author. School of Pharmacy, South-Central University for Nationalities, Wuhan 430074, China. Tel.: +86 27 6784 1196; fax: +86 27 6784 1196.School of Pharmacy, South-Central University for Nationalities, Wuhan 430074, ChinaSchool of Pharmacy, South-Central University for Nationalities, Wuhan 430074, ChinaSchool of Pharmacy, South-Central University for Nationalities, Wuhan 430074, ChinaSchool of Pharmacy, South-Central University for Nationalities, Wuhan 430074, ChinaDepartment of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing 210009, ChinaLuteolin (LUT) is one of the most common flavonoids present in various fruits and vegetables. The effects of luteolin (LUT) on streptozotocin (STZ)-induced diabetic renal damage were investigated. LUT was orally administered at 10, 20 mg/kg/day for 4 weeks to streptozotocin-induced diabetic mice. Serum levels of uric acid, creatinine, triacylglycerol, total cholesterol, low density lipoprotein and blood urea nitrogen were measured. Urinary uric acid and creatinine were assayed. Serum insulin level and oral glucose tolerance test (OGTT) were determined. Kidney pathological changes were detected. Receptor-interacting protein 140 (RIP140)/nuclear factor кB (NF-кB) pathway and insulin signalling pathway were detected. LUT restored streptozotocin-induced insulin resistance, dyslipidaemia, hyperuricemia, and renal inflammatory cell infiltration in streptozotocin-induced mice. Furthermore, LUT inhibited RIP140/NF-кB pathway and improved the insulin signalling pathway in streptozotocin-induced renal damage in mice. Thus, the beneficial effect of LUT against diabetic nephropathy (DN) is related to its regulation of RIP140/NF-кB and insulin pathway.http://www.sciencedirect.com/science/article/pii/S1756464616000268LuteolinRenal damageInflammationRIP140NF-кB pathwayInsulin signalling pathway |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lvyi Chen Guowen Tian Weidong Tang Wei Luo Peng Liu Zhanqiang Ma |
spellingShingle |
Lvyi Chen Guowen Tian Weidong Tang Wei Luo Peng Liu Zhanqiang Ma Protective effect of luteolin on streptozotocin-induced diabetic renal damage in mice via the regulation of RIP140/NF-кB pathway and insulin signalling pathway Journal of Functional Foods Luteolin Renal damage Inflammation RIP140 NF-кB pathway Insulin signalling pathway |
author_facet |
Lvyi Chen Guowen Tian Weidong Tang Wei Luo Peng Liu Zhanqiang Ma |
author_sort |
Lvyi Chen |
title |
Protective effect of luteolin on streptozotocin-induced diabetic renal damage in mice via the regulation of RIP140/NF-кB pathway and insulin signalling pathway |
title_short |
Protective effect of luteolin on streptozotocin-induced diabetic renal damage in mice via the regulation of RIP140/NF-кB pathway and insulin signalling pathway |
title_full |
Protective effect of luteolin on streptozotocin-induced diabetic renal damage in mice via the regulation of RIP140/NF-кB pathway and insulin signalling pathway |
title_fullStr |
Protective effect of luteolin on streptozotocin-induced diabetic renal damage in mice via the regulation of RIP140/NF-кB pathway and insulin signalling pathway |
title_full_unstemmed |
Protective effect of luteolin on streptozotocin-induced diabetic renal damage in mice via the regulation of RIP140/NF-кB pathway and insulin signalling pathway |
title_sort |
protective effect of luteolin on streptozotocin-induced diabetic renal damage in mice via the regulation of rip140/nf-кb pathway and insulin signalling pathway |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2016-04-01 |
description |
Luteolin (LUT) is one of the most common flavonoids present in various fruits and vegetables. The effects of luteolin (LUT) on streptozotocin (STZ)-induced diabetic renal damage were investigated. LUT was orally administered at 10, 20 mg/kg/day for 4 weeks to streptozotocin-induced diabetic mice. Serum levels of uric acid, creatinine, triacylglycerol, total cholesterol, low density lipoprotein and blood urea nitrogen were measured. Urinary uric acid and creatinine were assayed. Serum insulin level and oral glucose tolerance test (OGTT) were determined. Kidney pathological changes were detected. Receptor-interacting protein 140 (RIP140)/nuclear factor кB (NF-кB) pathway and insulin signalling pathway were detected. LUT restored streptozotocin-induced insulin resistance, dyslipidaemia, hyperuricemia, and renal inflammatory cell infiltration in streptozotocin-induced mice. Furthermore, LUT inhibited RIP140/NF-кB pathway and improved the insulin signalling pathway in streptozotocin-induced renal damage in mice. Thus, the beneficial effect of LUT against diabetic nephropathy (DN) is related to its regulation of RIP140/NF-кB and insulin pathway. |
topic |
Luteolin Renal damage Inflammation RIP140 NF-кB pathway Insulin signalling pathway |
url |
http://www.sciencedirect.com/science/article/pii/S1756464616000268 |
work_keys_str_mv |
AT lvyichen protectiveeffectofluteolinonstreptozotocininduceddiabeticrenaldamageinmiceviatheregulationofrip140nfkbpathwayandinsulinsignallingpathway AT guowentian protectiveeffectofluteolinonstreptozotocininduceddiabeticrenaldamageinmiceviatheregulationofrip140nfkbpathwayandinsulinsignallingpathway AT weidongtang protectiveeffectofluteolinonstreptozotocininduceddiabeticrenaldamageinmiceviatheregulationofrip140nfkbpathwayandinsulinsignallingpathway AT weiluo protectiveeffectofluteolinonstreptozotocininduceddiabeticrenaldamageinmiceviatheregulationofrip140nfkbpathwayandinsulinsignallingpathway AT pengliu protectiveeffectofluteolinonstreptozotocininduceddiabeticrenaldamageinmiceviatheregulationofrip140nfkbpathwayandinsulinsignallingpathway AT zhanqiangma protectiveeffectofluteolinonstreptozotocininduceddiabeticrenaldamageinmiceviatheregulationofrip140nfkbpathwayandinsulinsignallingpathway |
_version_ |
1721499812184981504 |