T Cell-Specific Overexpression of Acid Sphingomyelinase Results in Elevated T Cell Activation and Reduced Parasitemia During Plasmodium yoelii Infection

T Cell-Specific Overexpression of Acid Sphingomyelinase Results in Elevated T Cell Activation and Reduced Parasitemia During Plasmodium yoelii Infection

The enzyme acid sphingomyelinase (ASM) hydrolyzes sphingomyelin to ceramide and is thereby involved in several cellular processes such as differentiation, proliferation, and apoptosis in different cell types. However, the function of ASM in T cells is still not well characterized. Here, we used T ce...

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Bibliographic Details
Main Authors: Matthias Hose, Anne Günther, Hanna Abberger, Salina Begum, Marek Korencak, Katrin A. Becker, Jan Buer, Astrid M. Westendorf, Wiebke Hansen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
sphingolipids
acid sphingomyelinase
T cells
T cell activation
malaria
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01225/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01225/full

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