ADP-Ribosylation Regulates the Signaling Function of IFN-γ

ADP-Ribosylation Regulates the Signaling Function of IFN-γ

Murine T cells express the GPI-anchored ADP-ribosyltransferase 2.2 (ARTC2.2) on the cell surface. In response to T cell activation or extracellular NAD+ or ATP-mediated gating of the P2X7 ion channel ARTC2.2 is shed from the cell surface as a soluble enzyme. Shedding alters the target specificity of...

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Bibliographic Details
Main Authors: Stephan Menzel, Tomas Koudelka, Björn Rissiek, Friedrich Haag, Catherine Meyer-Schwesinger, Andreas Tholey, Friedrich Koch-Nolte
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
purinergic signaling
ADP-ribosylation
T cells
interferon-gamma
NAD+
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.642545/full

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