Altered Purinergic Receptor Sensitivity in Type 2 Diabetes-Associated Endothelial Dysfunction and Up<sub>4</sub>A-Mediated Vascular Contraction

Altered Purinergic Receptor Sensitivity in Type 2 Diabetes-Associated Endothelial Dysfunction and Up<sub>4</sub>A-Mediated Vascular Contraction

Purinergic signaling may be altered in diabetes accounting for endothelial dysfunction. Uridine adenosine tetraphosphate (Up<sub>4</sub>A), a novel dinucleotide substance, regulates vascular function via both purinergic P1 and P2 receptors (PR). Up<sub>4</sub>A enhances vascu...

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Bibliographic Details
Main Authors: Ali Mahdi, Tong Jiao, Yahor Tratsiakovich, Jiangning Yang, Claes-Göran Östenson, John Pernow, Zhichao Zhou
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:International Journal of Molecular Sciences
Subjects:
purinergic receptors
endothelial dysfunction
Up<sub>4</sub>A
vascular contraction
diabetes
Online Access:https://www.mdpi.com/1422-0067/19/12/3942

Internet

https://www.mdpi.com/1422-0067/19/12/3942

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