In vitro intestinal permeability studies, pharmacokinetics and tissue distribution of 6-methylcoumarin after oral and intraperitoneal administration in Wistar rats

In vitro intestinal permeability studies, pharmacokinetics and tissue distribution of 6-methylcoumarin after oral and intraperitoneal administration in Wistar rats

ABSTRACT 6-Methylcoumarin (6MC) is a semisynthetic coumarin with important in vitro and in vivo anti-inflammatory activity. In order to continue the pre-clinical characterization of this molecule, in vitro intestinal permeability, plasma profile and tissue distribution after oral administration in r...

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Bibliographic Details
Main Authors: Paola Andrea Cárdenas, Jadel Müller Kratz, Aura Hernández, Geison Modesti Costa, Luis Fernando Ospina, Yolima Baena, Cláudia Maria Oliveira Simões, Álvaro Jimenez-Kairuz, Marcela Aragon
Format: Article
Language:English
Published: Universidade de São Paulo 2017-04-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
6-Methylcoumarin/Pharmacokinetics/rats
6-Methylcoumarin/distribution
Intestinal permeability/study
Intestinal permeability/study/In vitro
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100621&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100621&lng=en&tlng=en

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