Iron-Bound Lipocalin-2 from Tumor-Associated Macrophages Drives Breast Cancer Progression Independent of Ferroportin

Iron-Bound Lipocalin-2 from Tumor-Associated Macrophages Drives Breast Cancer Progression Independent of Ferroportin

Macrophages supply iron to the breast tumor microenvironment by enforced secretion of lipocalin-2 (Lcn-2)-bound iron as well as the increased expression of the iron exporter ferroportin (FPN). We aimed at identifying the contribution of each pathway in supplying iron for the growing tumor, thereby f...

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Bibliographic Details
Main Authors: Christina Mertens, Matthias Schnetz, Claudia Rehwald, Stephan Grein, Eiman Elwakeel, Andreas Weigert, Bernhard Brüne, Michaela Jung
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Metabolites
Subjects:
tumor-associated macrophages (TAM)
iron
ferroportin
lipocalin-2
iron-trafficking
tumor microenvironment
Online Access:https://www.mdpi.com/2218-1989/11/3/180

Internet

https://www.mdpi.com/2218-1989/11/3/180

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