Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer

Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer

Cancer cells exhibit increased use of nutrients, including glucose and glutamine, to support the bioenergetic and biosynthetic demands of proliferation. We tested the small-molecule inhibitor of glutaminase CB-839 in combination with erlotinib on epidermal growth factor receptor (EGFR) mutant non-sm...

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Bibliographic Details
Main Authors: Milica Momcilovic, Sean T. Bailey, Jason T. Lee, Michael C. Fishbein, Clara Magyar, Daniel Braas, Thomas Graeber, Nicholas J. Jackson, Johannes Czernin, Ethan Emberley, Matthew Gross, Julie Janes, Andy Mackinnon, Alison Pan, Mirna Rodriguez, Melissa Works, Winter Zhang, Francesco Parlati, Susan Demo, Edward Garon, Kostyantyn Krysan, Tonya C. Walser, Steven M. Dubinett, Saman Sadeghi, Heather R. Christofk, David B. Shackelford
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cell Reports
Subjects:
EGFR
lung cancer
glutamine
erlotinib
CB-839
PET imaging
AMPK
metabolic crisis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716317685

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http://www.sciencedirect.com/science/article/pii/S2211124716317685

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