Perifosine and CCI 779 co-operate to induce cell death and decrease proliferation in PTEN-intact and PTEN-deficient PDGF-driven murine glioblastoma.

Perifosine and CCI 779 co-operate to induce cell death and decrease proliferation in PTEN-intact and PTEN-deficient PDGF-driven murine glioblastoma.

Platelet derived growth factor receptor (PDGFR) activity is deregulated in human GBM due to amplification and rearrangement of the PDGFR-alpha gene locus or overexpression of the PDGF ligand, resulting in the activation of downstream kinases such as phosphatidylinositol 3-kinase (PI3K), Akt, and mam...

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Main Authors: Kenneth L Pitter, Craig J Galbán, Stefanie Galbán, Omid Saeed Tehrani, Fei Li, Nikki Charles, Michelle S Bradbury, Oren J Becher, Thomas L Chenevert, Alnawaz Rehemtulla, Brian D Ross, Eric C Holland, Dolores Hambardzumyan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3022633?pdf=render

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http://europepmc.org/articles/PMC3022633?pdf=render

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