Repurposing antitussive benproperine phosphate against pancreatic cancer depends on autophagy arrest

Repurposing antitussive benproperine phosphate against pancreatic cancer depends on autophagy arrest

Pancreatic cancer (PC) is one of the most common human malignancies worldwide and remains a major clinical challenge. Here, we found that benproperine phosphate (BPP), a cough suppressant, showed a significant anticancer effect on PC both in vitro and in vivo via the induction of autophagy‐mediated...

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Bibliographic Details
Main Authors: Huanyu Zhang, Zhe Zhang, Yonghao Huang, Siyuan Qin, Li Zhou, Ningna Weng, Jiayang Liu, Mei Yang, Xiaodian Zhang, Yanda Lu, Lin Ma, Shaojiang Zheng, Qifu Li
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Molecular Oncology
Subjects:
autophagy arrest
benproperine phosphate
drug repurposing
pancreatic cancer
RAB11A
Online Access:https://doi.org/10.1002/1878-0261.12854

Internet

https://doi.org/10.1002/1878-0261.12854

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