Cohesin depleted cells rebuild functional nuclear compartments after endomitosis

Cohesin depleted cells rebuild functional nuclear compartments after endomitosis

The role of cohesin in organizing a functional nuclear architecture remains poorly understood. Here the authors show that cohesin depleted cells pass through endomitosis forming a multilobulated nucleus able to proceed through S-phase with typical features of active and inactive nuclear compartments...

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Bibliographic Details
Main Authors: Marion Cremer, Katharina Brandstetter, Andreas Maiser, Suhas S. P. Rao, Volker J. Schmid, Miguel Guirao-Ortiz, Namita Mitra, Stefania Mamberti, Kyle N. Klein, David M. Gilbert, Heinrich Leonhardt, M. Cristina Cardoso, Erez Lieberman Aiden, Hartmann Harz, Thomas Cremer
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19876-6

Internet

https://doi.org/10.1038/s41467-020-19876-6

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