Cohesin depleted cells rebuild functional nuclear compartments after endomitosis
The role of cohesin in organizing a functional nuclear architecture remains poorly understood. Here the authors show that cohesin depleted cells pass through endomitosis forming a multilobulated nucleus able to proceed through S-phase with typical features of active and inactive nuclear compartments...
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Bibliographic Details
Main Authors: |
Marion Cremer,
Katharina Brandstetter,
Andreas Maiser,
Suhas S. P. Rao,
Volker J. Schmid,
Miguel Guirao-Ortiz,
Namita Mitra,
Stefania Mamberti,
Kyle N. Klein,
David M. Gilbert,
Heinrich Leonhardt,
M. Cristina Cardoso,
Erez Lieberman Aiden,
Hartmann Harz,
Thomas Cremer |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2020-12-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-020-19876-6
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